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DNA / RNA Oligonucleotide Synthesizers

  MM-4 MM-6 MM-12 MM-192 MM-384 ABI 3900 ABI 3400 ABI Expedite 8909 w/MOSS (discontinued) Gene Machines Polyplex
Number of oligos synthesized without user intervention 4 6 12 192 384 48 4 16 96
Number of oligos Synthesized Simultaneously 4 6 12 192 384 48 4 2 96
Number of 20-mers produced in a given time 4 in 2.5 hours 6 in 2 hours 12 in 2.5 hours 384 in 10 hours 384 in 6 hours 288 in 10 hours 4-25mers in 4 hours (cleavage included) 2 in 2.5hours 96 in 3 hours
Scale Range 50-5000nmole 50-50000nmole 50-50000nmole 5-5000nmole 5-5000nmole 40-1000nmole 40-1000nmole 40-15000nmole up to 1000nmole
Number of Amidite ports 10 10+ 10+ 10+ 10+ 7 for each bank of 24 8 9 8
96 well format       X X       X
Trityl Collect/monitor X X X       X X X
Columns or plate synthesis       X X       X
Efficient reagent use X X X X X X X X continues to add Ancillary reagents after oligo is completed if different lengths are being synthesized
Dedicated Thio Bottle X X X X X   X X  
Computer and software included and pre configured X X X X X X     ?
Short cycle times X X X X X X X X X
World Wide service X X X X X X X X X
Standard RNA protocols